sábado, 4 de junio de 2016

ASCO's New Guideline for Endocrine Therapy in Breast Cancer June 01, 2016

Key Recommendations for Women With HR-Positive Metastatic Breast Cancer
Hormone therapy should be offered to patients whose tumors express any level of estrogen and/or progesterone receptors, and treatment recommendations should be based on factors such as the type of adjuvant treatment being administered, disease-free interval, and the extent of disease at the time of recurrence
Use of a specific agent can be repeated if recurrence happens more than 12 months after the last treatment
Endocrine therapy should be recommended as the initial treatment in this patient population, except in the case of immediate life-threatening disease or rapid disease recurrence during adjuvant endocrine therapy
The use of combination endocrine therapy and chemotherapy is not recommended
For first-line therapy
 Postmenopausal women should be offered aromatase inhibitors (AIs)
 Combination hormone therapy with a nonsteroidal AI and fulvestrant (Faslodex, AstraZeneca) 500 mg and with a loading-dose schedule can be offered to patients who have not previously used endocrine therapy
 Premenopausal women should be offered ovarian suppression or ablation and hormone therapy; current agents have only been studied in the postmenopausal population
For second-line therapy
 Sequential hormone therapy should be offered except for those with rapid progression and organ dysfunction
 If fulvestrant is given, a 500 mg dose should be used, and with a loading schedule
For targeted therapy
 Postmenopausal women can be offered a nonsteroidal AI and palbociclib (Ibrance, Pfizer)
 Exemestane (Aromasin, Pfizer) and everolimus (Afinitor, Novartis) can be offered to postmenopausal women who progressed with nonsteroidal AIs, either before or after treatment with fulvestrant
 Fulvestrant and palbociclib can be offered to patients who experienced progression with AIs, with or without prior chemotherapy
 Adding HER2-targeted therapy to first-line AIs should be offered to patients with HR-positive and HER2-positive disease if they are not candidates for chemotherapy
 Genomic or expression profiling should not be used at this time to select treatment for metastatic HR-positive breast cancer

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